Neurofibromatosis type I (NF-1) is a complex multi-system human disorder caused by the mutation of a gene on chromosome 17 that is responsible for production of a protein, called neurofibromin, which is needed for normal function in many human cell types.
Cafe au lait macule ibonwe kwi Neurofibromatosis type 1 (NF-1)
Neurofibromatosis yimeko ebangela amathumba kwi-nervous system kunye nolusu. Udidi loku-1 lufuzwe kakhulu kwaye lubonisa iimpawu ezinje nge neurofibromas, café-au-lait spots, freckling, and optic gliomas. Ukuxilongwa kusekelwe kwiimpawu zeklinikhi. Udidi lwesi-2, kwelinye icala, luphawulwe ngo bilateral vestibular schwannomas (VS) and meningiomas, nalo lizuzwe kakhulu. Ulawulo lubandakanya ukubekwa kweliso rhoqo kunye nonyango lwezonyango njengoko lufuneka kuzo zombini iindidi ze neurofibromatosis. Neurofibromatosis is a neurocutaneous disorder characterized by tumors in the nervous system and skin. Neurofibromatosis types 1 and 2 are the most common and are distinct entities. Neurofibromatosis type 1, or von Recklinghausen disease, is an autosomal dominant disease. Neurofibromatosis type 1 presents with neurofibromas, cafe-au-lait macules, freckling, and optic gliomas. It is a clinical diagnosis. Neurofibromatosis type 2 (NF2) is a disease characterized by bilateral vestibular schwannomas (VS) and meningiomas. It has an autosomal dominant inheritance pattern. Treatment for neurofibromatosis types 1 and 2 is clinical monitoring and medical intervention when appropriate.
Iimpawu eziqhelekileyo ze‑neurofibromatosis ziquka amabala amdaka‑bomvu kwindawo enemibala yeliso ebizwa ngokuba yi‑Lisch nodules kunye ne‑neurofibromas. Scoliosis (i‑curvature of the spine), ukukhubazeka kokufunda, ukuphazamiseka kokubona, ukukhubazeka kwengqondo, iindawo ezininzi ze‑café au lait kunye nokuxhuzula kunokukhatshwa.
Akukho nyango lukhethekileyo okwangoku.