Informationes plurimae ― Latine

Cutaneous angiofibromas in variis partibus corporis apparere possunt. In facie saepe nota sunt papulae fibrosae vel adenoma sebaceum; in penis dicuntur pearly penile papules; sub clavo angiofibromas seu tumores periunguales nominantur; et in ore fibromata oralia referuntur. Angiofibromata faciei, quae notae sunt tuberosae sclerosis (TS), sunt manifestatio huius disordini hereditarii, quod cutem, renes, cor, cerebrum et pulmonem afficit. Morem faciunt in facie in pueritia vel iuventute, in singulis cum TS. Habentes tres vel plures angiofibromata facialis vel duo vel plures angiofibromata periungualia, consideratur signum in diagnosi TS. Accedit multiplex angiofibromata faciei in conditionibus (multiple endocrine neoplasia type 1 (MEN‑1) et Birt‑Hogg‑Dubé syndrome). Pearly penile papules in margine coronali et sulco penis reperiuntur. Pervicaces, sine dolore, communiter in praeputio virorum apparent.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.