Meskipun soft fibroma biasanya muncul pada lipatan kulit seperti leher, ketiak, dan area genital, penyakit ini juga dapat, meskipun jarang, muncul pada puting susu. Dokter harus mengingat soft fibroma saat mengevaluasi kelainan pada puting. Although soft fibromas occur in the intertriginous area, including on the neck, axillae, and vulvovaginal locations, in rare cases, they can develop in the nipple. Doctors should consider soft fibroma as one of the differential diagnoses for nipple lesions.