Plis enfomasyon ― Kreyòl ayisyen

Urticarial vasculitis se yon kondisyon po ki karakterize pa lezyon itikè ki pèsiste; sou istoloji, lezyon sa yo montre vaskilitis. Li se yon antite klinik‑patolojik ki ra, ki karakterize pa epizòd kwonik oswa repete de lezyon itikè. Lezyon po sa yo ka difisil pou distenge vizyèlman de itikè idiopatik kwonik, men yo inik paske chak lezyon dire pou ≥ 24 èdtan epi ka kite dèyè ipèpigmantasyon fènwa. Maladi a souvan idiopatik, men li ka lye ak sèten medikaman, enfeksyon, maladi otoiminitè, maladi san, oswa kansè. Gen kèk etid ki menm lye li ak COVID‑19 ak grip H1N1. Li kapab tou afekte lòt sistèm kò a tankou misk, ren, poumon, vant, ak je. Pandan ke egzamen tisi ki montre karakteristik vaskilitis leykositoklòfatik souvan konfime dyagnostik la, li pa toujou obligatwa. Tretman anjeneral kòmanse ak antibyotik, dapsone, kolchisin, oswa idroksiklorokin pou ka ki pi modere. Pou ka ki pi grav, dwòg ki siprime sistèm iminitè a tankou methotrexate, mycophenolate mofetil, azathioprine, cyclosporine, ansanm ak kortikostewoyid (corticosteroids), ka nesesè pou kontwole maladi a. Dènyèman, terapi byolojik tankou rituximab, omalizumab, ak enkibatè entèlikin‑1 (interleukin‑1 inhibitors) te montre pwomès pou ka ki difisil.
Urticarial vasculitis is a rare clinicopathologic entity that is characterized by chronic or recurrent episodes of urticarial lesions. Skin findings of this disease can be difficult to distinguish visually from those of chronic idiopathic urticaria but are unique in that individual lesions persist for ≥24 hours and can leave behind dusky hyperpigmentation. This disease is most often idiopathic but has been linked to certain drugs, infections, autoimmune connective disease, myelodysplastic disorders, and malignancies. More recently, some authors have reported associations between urticarial vasculitis and COVID-19, as well as influenza A/H1N1 infection. Urticarial vasculitis can extend systemically as well, most often affecting the musculoskeletal, renal, pulmonary, gastrointestinal, and ocular systems. Features of leukocytoclastic vasculitis seen on histopathologic examination are diagnostic of this disease, but not always seen. In practice, antibiotics, dapsone, colchicine, and hydroxychloroquine are popular first-line therapies, especially for mild cutaneous disease. In more severe cases, immunosuppressives, including methotrexate, mycophenolate mofetil, azathioprine, and cyclosporine, as well as corticosteroids, may be necessary for control. More recently, select biologic therapies, including rituximab, omalizumab, and interleukin-1 inhibitors have shown promise for the treatment of recalcitrant or refractory cases.

Yon nonm 35‑zan te vini ak yon istwa 15‑jou nan wouj klere, gratèl ki fè mal sou tou de kwis ak janm, ansanm ak doulè nan jwenti. Li te gen yon enfeksyon aparèy urinè (urinary tract infection) pou yon semèn anvan gratèl la parèt. Po l 'te montre plizyè sansib, ki gen fòm bag, pasyèlman blanch, plak wouj sou tou de bò kwis li ak janm li. Li te bay oral prednisolone (40 mg/jou) pou yon semèn ansanm ak yon antihistamin ki pa somnolans (fexofenadine). Nan yon semèn, tout gratèl yo disparèt nèt. Pa te gen okenn erupsyon plis pandan 6 mwa pwochen yo nan tchek‑up regilye.
A 35-year-old man came in with a 15-day history of bright red, painful rashes on both thighs and legs, along with joint pain. He had a urinary tract infection for a week before the rash appeared. His skin showed several tender, ring-shaped, partially blanchable, red plaques on both sides of his thighs and legs. He was given oral prednisolone (40mg/day) for a week along with a non-drowsy antihistamine (fexofenadine). Within a week, all the rashes disappeared completely. There were no more rashes during the next 6 months of regular check-ups.