Mens soft fibroma typisk forekommer i hudfolder som nakke, armhuler og kønsorganer, kan de også, omend sjældent, forekomme på brystvorten. Læger bør huske soft fibroma, når de vurderer abnormiteter i brystvorten. Although soft fibromas occur in the intertriginous area, including on the neck, axillae, and vulvovaginal locations, in rare cases, they can develop in the nipple. Doctors should consider soft fibroma as one of the differential diagnoses for nipple lesions.