Meer inligting ― Afrikaans

Keratoacanthoma (KA) is 'n gereelde velgewas wat bekend is vir sy vinnige groei en die potensiaal om op sy eie te regresseer. Dit kom tipies voor by ouer mans met 'n ligte vel en 'n geskiedenis van sonskade. Terwyl chirurgiese verwydering met uitsny of Mohs‑mikrografiese chirurgie die gewone behandeling is, is daar verskeie ander terapie‑opsies beskikbaar.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.

Keratoacanthoma (KA) is 'n laaggradige gewas wat in sekere kliere in die vel begin en onder 'n mikroskoop lyk dit soortgelyk aan squamous cell carcinoma (SCC). Daar is voortdurende debat oor of KA as 'n vorm van indringende SCC geklassifiseer moet word.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.

Cutaneous squamous cell carcinoma (cSCC) is die tweede mees algemene vorm van kanker by mense, veral onder ouer individue. Chirurgie word tipies gebruik om cSCC te behandel, maar vir pasiënte wat nie chirurgie kan ondergaan of verkies om dit nie te doen nie, kan ander opsies, soos intralesionale behandelings, oorweeg word. Tradisionele intralesionale behandelings, soos methotrexate of 5-fluorouracil, word gebruik, maar daar is voortdurende navorsing oor nuwe benaderings soos intralesionale immunoterapie en onkolitiese viroterapie. Hier sal ons verskillende intralesionale behandelings vir cSCC bespreek, wat wissel van klassieke metodes tot die nuutste strategieë.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.