Intraepithelial carcinoma (Bowen disease) toon atipiese plaveisel‑selleproliferasie deur die hele dikte van die epidermis. Die hele gewas is beperk tot die epidermis en dring nie in die dermis in nie. Hierdie siekte word tegnies as kankeragtig geklassifiseer, maar is nie‑indringend, in teenstelling met gewone kankers (m.a.w. dit is ’n kanker met ’n goeie prognose).
Dit verskyn gewoonlik as ’n eritematiese, skubberige of korsagtige area op enige plek op die liggaam. Die mees algemene plek is onderbene.
Dit is geneesbaar deur verskeie behandelingsopsies, soos krioterapie, curettage, koutering, fotodinamiese terapie of uitsny van die lesie.
Squamous-cell skin cancer is one of the main types of skin cancer along with basal cell cancer, and melanoma. It usually presents as a hard lump with a scaly top but can also form an ulcer. Onset is often over months. Squamous-cell skin cancer is more likely to spread to distant areas than basal cell cancer. When confined to the outermost layer of the skin, a precancerous or in situ form of cSCC is known as Bowen's disease.
Tipiese geval ― Intraepithelial carcinoma (Bowen disease) kan verkeerd gediagnoseer word as 'n langdurige, nie-jeukerige ekseem.
Cutaneous horn – anders as vratte, dit presenteer as ’n harde knop, en ’n biopsie is nodig om kwaadaardigheid uit te sluit.
As 'n wond vir 'n lang tydperk voortduur, moet velkanker oorweeg word.
Bowen's disease (BD) is 'n tipe velkanker wat in die buitenste laag van die vel (epidermis) begin. Dit kom meer algemeen voor by Kaukasiërs en word dikwels aangetref in gebiede wat aan sonlig blootgestel word, maar dit kan ook elders voorkom. BD verskyn tipies as 'n enkele letsel. BD word dikwels gesien as 'n waarskuwingsteken voordat 'n meer ernstige tipe velkanker ontwikkel. Om BD te diagnoseer, maak dokters gewoonlik staat op die ondersoek van weefselmonsters onder 'n mikroskoop (biopsie). Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease raak meestal wit individue ouder as 60. Sleutelrisikofaktore sluit in langtermyn sonblootstelling, 'n verswakte immuunstelsel, arseenblootstelling en vel‑HPV‑infeksie. HPV‑stamme 16, 18, 34 en 48 word gekoppel aan Bowen se siekte in genitale areas. Die betrokkenheid van HPV in nie‑genitale gevalle is minder duidelik. Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Dit verskyn gewoonlik as ’n eritematiese, skubberige of korsagtige area op enige plek op die liggaam. Die mees algemene plek is onderbene.
Dit is geneesbaar deur verskeie behandelingsopsies, soos krioterapie, curettage, koutering, fotodinamiese terapie of uitsny van die lesie.
○ Diagnose en behandeling
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy